Hi mack5858,
Not sure what "Powerdesk pro" is used for.
The MPx players are really easy to download music on. Think of it as a "removable USB memory stick", that's the easiest way to use it.
Once you plug your MPx player into your computer through the USB, it will come up as a drive (in your case "e" I believe). Then just use plan Windows Explorer and copy and paste the music from your computer onto that drive. Much like copying a file from one location to another.
Once you finish, make sure you remove the device safely from your computer rather than just unplugging it off the USB cable.
Hope that helps.
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