Both Sansa E-series and C-series players use lithium batteries, but the Es are enclosed while the Cs are removable. Both have micro SD slot but support only up to 2GB without Rockbox (then up to 8GB, I think). Not sure about my son's E-250 but my C-250 can play when charging; I have it hooked up to a pair of computer speakers and a USB wall charger next to the bed. Hopefully Rockbox will continue to add to their list of supported players.
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